preparation of novel anti-breast cancer vaccine by nanoencapsulation technique from biopolymer (lactide-co-glycolic).

Effect of nanoencapsulation on the phenomenon of drug interaction between anti-M.avium drug, rifabutin and anti-HIV drug, ritonavir by employing poly (lactide-co-glycolide) nanoparticles

Background Interaction between M.avium and HIV drugs is unavoidable in HIV patients as for an improved life expectancy of HIV patients, additional medications have to be administered along with HIV drugs. The anti-M.avium drug rifabutin and protease inhibitor, ritonavir are associated with significant drug interactions involving the cytochrome P450 (CYP) enzyme system. Little information is ava...

Design of a Novel Recombinant Multi-Epitope Vaccine against Triple-Negative Breast Cancer

Background: Triple-negative breast cancer (TNBC) is determined by the absence of ERBB2, estrogen and progesterone receptors’ expression. Cancer vaccines, as the novel immunotherapy strategies, have emerged as promising tools   for treating the advanced stage of TNBC. The aim of this study was to evaluate Carcinoembryonic antigen (CEA), Metadherin (MTDH), and Mucin 1 (MUC-1) proteins as vaccine ...

Comparison of Structural Modification and Argon Plasma Treatment of Poly(lactide-co-glycolic acid) Nanofibrous Scaffolds for Cell Culture

Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention

Pomegranate polyphenols are potent antioxidants and chemopreventive agents but have low bioavailability and a short half-life. For example, punicalagin (PU), the major polyphenol in pomegranates, is not absorbed in its intact form but is hydrolyzed to ellagic acid (EA) moieties and rapidly metabolized into short-lived metabolites of EA. We hypothesized that encapsulation of pomegranate polyphen...

Inhibition of breast cancer metastasis by co-transfection of miR-31/193b-mimics

Objective(s): Various studies have been conducted to reduce the metastatic behavior of cancerous cells. In this regard, ectopic expression of anti-metastatic microRNAs by miR-mimic and miR-restoration-based therapies could bring new insights to the field. In the present study, the consequences of co-transfecting breast cancer cell lines with miR-193b and miR-31 were investigated via invasion an...

Poly(DL-lactide-co-glycolic acid) nanoparticle design and payload prediction: a molecular descriptor based study.

Polymer nanoparticles are veritable tools for pharmacokinetic and therapeutic modifications of bioactive compounds. Nanoparticle technology development and scaling up are however often constrained due to poor payload and improper particle dissolution. This work was aimed to develop descriptor based computational models as prior art tools for optimal payload in polymeric nanoparticles. Loading o...